With two lines given by their direction vectors, two natural quantities arise: the angle between them and (if they do not meet) the shortest distance.
Angle between two lines
If the lines have direction vectors $\vec b_1,\vec b_2$, the angle $\theta$ between them satisfies
$$\cos\theta=\frac{|\vec b_1\cdot\vec b_2|}{|\vec b_1||\vec b_2|}.$$
They are perpendicular if $\vec b_1\cdot\vec b_2=0$ and parallel if $\vec b_1\times\vec b_2=\vec 0$.
Shortest distance between skew lines
For lines $\vec r=\vec a_1+\lambda\vec b_1$ and $\vec r=\vec a_2+\mu\vec b_2$, the shortest distance is
$$d=\frac{\left|(\vec a_2-\vec a_1)\cdot(\vec b_1\times\vec b_2)\right|}{|\vec b_1\times\vec b_2|}.$$
If $d=0$ the lines intersect (are coplanar). For parallel lines use $d=\dfrac{|(\vec a_2-\vec a_1)\times\vec b|}{|\vec b|}$.